Drug Standards
Medchemexpress LLC (3S,4S)-Tofacitinib | 1092578-47-6 | MFCD11035920 | 99.8% | 312.37 g/mol | C16H20N6O | 10 MG
(3S,4S)-Tofacitinib is the S-enantiomer of the JAK inhibitor tofacitinib and is provided as a research reference compound for biochemical and cellular studies. It is reported to be less active than the clinical racemate and is characterized by CAS 1092578-47-6, formula C16H20N6O, and molecular weight 312.37 g/mol.
- Enantiomeric reference for JAK signaling studies.
- High purity (99.75%) suitable for analytical and biochemical assays.
- Molecular formula C16H20N6O and molecular weight 312.37 g/mol.
- Supplied as a 10 mg research quantity.
- Useful as a reference standard for selectivity and potency comparisons.
Sigma Aldrich Fine Chemicals Biosciences Trifluridine Related Compound A United States Pharmacopeia (USP) Reference Standard | 14599-46-3 | 10MG
Trifluridine Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 272.21 | 14599-46-3 | 10MG
eMolecules Fexofenadine, HCl | 153439-40-8 | MFCD00865710 | 25g
Combi-Blocks | Fexofenadine, HCl | 25g | 335361201 | QA-2272 | 98.000 | 153439-40-8 | MFCD00865710 | 538.130 | C32H40ClNO4
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Medchemexpress LLC Tofacitinib impurity 3 | 1616761-00-2 | 99.84% | C₁₆H₁₉ClN₆O | 5 MG
Tofacitinib impurity 3 is an impurity of Tofacitinib, primarily used as a laboratory chemical and for the manufacture of substances.
- Suitable for laboratory use.
- Used in the manufacture of substances.
- Store sealed at 4°C, away from moisture.
- Stable in solvent at -80°C for 6 months, or -20°C for 1 month.
- Can be shipped at room temperature if less than 2 weeks.
Selleck Chemical LLC Encorafenib (LGX818) 5mg 1269440-17-6
Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences beta-Acetyldigoxin European Pharmacopoeia (EP) Reference Standard | 5355-48-6 |
beta-Acetyldigoxin European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.98 | 5355-48-6 |
Apexbio Technology LLC Nitisinone 104206-65-7 10mM (in 1mL DMSO)
Nitisinone (CAS 104206-65-7) is a synthetic small molecule that selectively inhibits 4-hydroxyphenylpyruvate dioxygenase an enzyme involved in the catabolic pathway of tyrosine By blocking this enzyme nitisinone disrupts the conversion of 4-hydroxyphenylpyruvate to homogentisic acid leading to reduced production of toxic tyrosine metabolites This mechanism is utilized in studies of hereditary tyrosinemia type 1 where nitisinone serves as a pharmacological tool to investigate metabolic regulation and therapeutic intervention in tyrosine degradation disorders
Medchemexpress LLC Lenalidomide-5-Br | 1010100-26-1 | 99.9% | 323.15 g·mol⁻¹ | C13H11BrN2O3 | 1 G
Lenalidomide-5-Br is a lenalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ubiquitin ligase for chemical biology applications. It is supplied as a research-grade building block for PROTAC design, where it can be conjugated to a protein-targeting ligand via a linker.
- Lenalidomide-derived CRBN ligand for recruitment of cereblon
- Suitable for PROTAC design and linker conjugation
- High purity appropriate for research use
- Available in multiple pack sizes (1 g-100 g)
- Molecular formula C13H11BrN2O3, molecular weight 323.15 g·mol⁻¹
Apexbio Technology LLC Tenofovir 147127-20-6 10mM (in 1mL DMSO)
Tenofovir is an antiviral compound acting as an inhibitor of HIV reverse transcriptase specifically targeting RNA-dependent DNA polymerase to impede the replication cycle of HIV It interferes with the transcription process by competitively binding to the enzyme thereby preventing viral RNA from being transcribed into complementary DNA In vitro investigations indicate that Tenofovir inhibits viral replication as evidenced by an IC50 value of approximately 1 5 M in SIV-infected C-8166 cell assays Due to this inhibitory mechanism and antiviral activity against HIV Tenofovir is widely employed in biomedical and pharmacological research focused on HIV infection antiviral drug development and related studies involving reverse transcriptase enzymatic activity
Medchemexpress LLC Niclosamide (olamine) | 1420-04-8 | 98.7% | 1 G
Niclosamide olamine is an orally active antihelminthic agent used in parasitic infection research. It functions as a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. This compound also exhibits biological activities against cancer and inhibits DNA replication in Vero E6 cells.
- Inhibits adrenocortical carcinoma cellular proliferation.
- Inhibits STAT3-mediated luciferase reporter activity in HeLa cells.
- Inhibits virus replication in Vero E6 cells.
- Inhibits adrenocortical carcinoma tumor growth in vivo.
Medchemexpress LLC Berberine hemisulfate | 316-41-6 | 384.40 | 5 G
Berberine hemisulfate is the hemisulfate form of Berberine. It is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective, and neuroprotective activity.
- Exhibits antimicrobial activity by inhibiting cell division protein FtsZ, or through DNA/RNA binding causing DNA/RNA damage.
- Exhibits anti-inflammatory activity by inhibiting TNF-α and the activation of its downstream pathway AP-1 and NF-kB.
- Exhibits neuroprotective efficacy by inhibiting reactive oxygen species (ROS) production and caspase activation, and activating the PI3K/Akt signaling pathway and heme oxygenase-1 (HO-1) expression.
- Attenuates metabolic diseases through regulations of lipid composition and inhibition of insulin resistance.
Medchemexpress LLC (S)-Ketorolac | 66635-92-5 | 99.3% | 25 MG
(S)-Ketorolac is a nonsteroidal anti-inflammatory agent that exhibits potent COX1 and COX2 enzyme inhibition.
- Target: COX1 and COX2
- Molecular formula: C15H13NO3
- Molecular weight: 255.27
- Appearance: White to off-white solid
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 2 years, -20°C for 1 year
- Solubility in DMSO: 200 mg/mL
Apexbio Technology LLC R788 disodium 1025687-58-4 5mg
R788 disodium (CAS 1025687-58-4) is a prodrug of the active metabolite R406 a selective inhibitor of spleen tyrosine kinase (Syk) Syk mediates signaling downstream of activated Fc and B-cell receptors (BCR) In vitro R406 suppresses constitutive and ligand-stimulated BCR signaling in diffuse large B-cell lymphoma (DLBCL) lines by inhibiting Syk autophosphorylation (SYK525/526) and associated phosphorylation of BLNK inducing apoptosis In vivo R788 reduces malignant B-cell proliferation and tumor progression in E -TCL1 mice Clinically R788 has shown utility in rheumatoid arthritis improving therapeutic response rates in phase II trials
Sigma Aldrich Fine Chemicals Biosciences Mycophenolate mofetil United States Pharmacopeia (USP) Reference Standard | 128794-94-5 | MFCD00867568 | 200MG
Mycophenolate mofetil United States Pharmacopeia (USP) Reference Standard | Mol Wt: 433.49 | 128794-94-5 | MFCD00867568 | 200MG
Medchemexpress LLC Benzoic-1,2,3,4,5,6-13C6 acid, 4-hydroxy-, butyl ester | 1416711-53-9 | 99.8% | 500 UG
Butylparaben-13C6 is the 13C labeled Butylparaben. Butylparaben is an organic compound that has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food. This compound is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS